PLASMA CORTISOL-LINKED GENE NETWORKS IN HEPATIC AND ADIPOSE TISSUES IMPLICATE CORTICOSTEROID-BINDING GLOBULIN IN MODULATING TISSUE GLUCOCORTICOID ACTION AND CARDIOVASCULAR RISK

Genome-wide association meta-analysis (GWAMA) by the Cortisol Network (CORNET) consortium identified genetic variants spanning the SERPINA6/SERPINA1 locus on chromosome 14 associated with morning plasma cortisol, cardiovascular disease (CVD), and SERPINA6 mRNA expression encoding corticosteroid-binding globulin (CBG) in the liver.These and other fi

Due to the release of hazardous Gas Filler Hose heavy metals from various industries, water pollution has become one of the biggest challenges for environmental scientists today.Mercury Hg(II) is regarded as one of the most toxic heavy metals due to its ability to cause cancer and other health issues.In this study, a tailor-made modern eco-friendly

Despite the advantages of ternary logic, it has suffered from excessive transistor count and limited noise margin.This work proposes an ultra-efficient nonvolatile ternary flip-flop (FF) based on negative capacitance carbon nanotube field-effect transistors (NC-CNTFETs).By harnessing the negative differential resistance effect in NC-CNTFETs, the pr

In view of problems of difficult management for field devices and hard to fulfill application of existing device management system Wire Ferrule in coal mine, the paper proposed a design scheme of dynamic management information system for coal mine devices.The system is based on uniform encoding management of devices in mine wide, takes responsible

Objective: Melanocortin 2 receptor accessory protein 2 (MRAP2) has a critical role in energy homeostasis.Although MRAP2 has been shown to regulates a number of GPCRs involved in metabolism, the key neurons responsible for the phenotype of gross obesity in MRAP2 deficient animals are unclear.Furthermore, to date, all the murine BRAIN B-12 1000MCG MR